Studies on the Therapeutic Modulation of Inflammation in the Synovial Membrane of Rheumatoid Arthritis
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6 Figures and Tables
Table 1. ACR 1987 criteria (left panel) were designed to classify established rheumatoid arthritis. 2010 ACR/EULAR criteria (right panel) are intended to classify both early and established disease.
Figure 1 Arthroscopic images of a normal joint with thin transparent synovium (A) and a joint with on going inflammation (early RA) where we can see hypertrophied synovium with villi formation and increased vascularity (B).
Figure 2 A schematic representation of a joint. A healthy joint to the left, with a thin synovial membrane, and an inflamed RA joint to the right, with a hypertrophied synovial membrane with massive influx of inflammatory cells.
Figure 3 Diapedesis of neutrophils. How the neutrophils pass from the peripheral blood to the site of inflammation.
Figure 4 Simplified picture that outlines the typical TNF-α actions that are relevant to the pathogenesis of RA. Adapted from Brennan et al 2008 
Figure 6 Immunohistochemical analysis of LL-37 expression in lungtissue from a patient with RA. LL-37 expression in cells with neutrophil morphology (A), negative control (B). Magnification x25
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